Lab Supply Pharmaceutical Intermediate Powder Peptide Mgf
Basic Info
Model No.: Mechano growth factor
Product Description
Model NO.: Mechano growth factor Customized: Customized Suitable for: Adult, Lab Research Purity: >98% Application: Pharmaceutical Appearance: Lyophilized Powder Specification: iu, mg, g, kg HS Code: 3004905910 Powder: Yes Certification: GMP State: Solid Product Name: Mgf Color: White Trademark: Filter Origin: Shanghai Lab Supply Pharmaceutical Intermediate Powder Peptide MGF
Description
MGF
Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation.
Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys
Molecular formula: C121H200N42O39
Molar Mass: 2867.14
CAS number: N/A
Synonyms: Mechano Growth Factor, IGF-1 Ec
Age Related Muscle Loss and MGF
MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia. It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.
How does Mechano Growth Factor work? - Muscle Growth!
When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene is released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary mechanism by which the body produces new muscle tissue.
Our process:
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of producs and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Our advantages:
1. Quality:
Our company is a professional production of hormone intermediates for many years, our products have exported to Germany,Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, you can trust us.
And we are the manufactory, so no problem for us to control the quality.
2.Payment method: Western Union,TT.
3.Service: Best service with after-sales service to all clients.
4.Delivery:
Sample Order :Package will be shipped with 3days after payment. We can send it via UP, EMS, HK Air Post, DHL or othermethod. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.
Other Peptide Our Lab Supply:
Contact us if you need more details on Pharmaceutical Intermediate. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Mgf、16679-58-6. If these products fail to match your need, please contact us and we would like to provide relevant information.
Description
MGF
Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation.
Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys
Molecular formula: C121H200N42O39
Molar Mass: 2867.14
CAS number: N/A
Synonyms: Mechano Growth Factor, IGF-1 Ec
Age Related Muscle Loss and MGF
MGF was suggested to play a number of physiological roles because the failure in its expression may result to age-related loss of skeletal function. Included in its functions is its ability to become a potent neuroprotective as supported by the study that has shown functional copies of the MGF cDNA to be expressed in a plasmid vector which then protected facial neurons after nerve damage (Dluzniewska et al. 2005). One such failure is called sarcopenia. It would also appear that with regards to age, the young have a better ability to respond to MGF (4), and that the elderly experience a decreased response to MGF which results in a decreased ability to stimulate the growth of new muscle tissue.
How does Mechano Growth Factor work? - Muscle Growth!
When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene is released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary mechanism by which the body produces new muscle tissue.
Our process:
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of producs and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Our advantages:
1. Quality:
Our company is a professional production of hormone intermediates for many years, our products have exported to Germany,Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, you can trust us.
And we are the manufactory, so no problem for us to control the quality.
2.Payment method: Western Union,TT.
3.Service: Best service with after-sales service to all clients.
4.Delivery:
Sample Order :Package will be shipped with 3days after payment. We can send it via UP, EMS, HK Air Post, DHL or othermethod. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.
Other Peptide Our Lab Supply:
| Product | Purity | CAS No. |
| Abarelix Acetate | 98% | 183552-38-7 |
| Alarelin Acetate | 98% | 79561-22-1 |
| Angiotensin Acetate | 98% | 58-49-1 |
| Angiotensin II | 98% | 68521-88-0 |
| Antide Acetate | 98% | 112568-12-4 |
| Argpressin Acetate | 98% | 113-79-1 |
| Argreline Acetate | 98% | 616204-22-9 |
| Atosiban Acetate | 98% | 90779-69-4 |
| Aviptadil Acetate | 98% | 40077-57-4 |
| Bate-Amyloid(1-42)human | 95% | 107761-42-2 |
| Bivalirudin Trifluoroacetate | 98% | 128270-60-0 |
| Buserelin acetate | 98% | 57982-77-1 |
| Calcitonin | 9007/12/9 | |
| Carbetocin Acetate | 98% | 37025-55-1 |
| Carperitide | 98% | 89213-87-6 |
| Cecropin B | 98% | |
| Cetrorelix Acetate | 98% | 130143-01-0 |
| Cetrorelix Acetate | 98% | 130143-01-0 |
| CJC-1295 | 98% | 863288-34-0 |
| Copper Peptide(GHK-Cu) | 98% | 49557-75-7 |
| CRF (human, rat) Acetate | 98% | 86784-80-7 |
| CRF (ovine) Trifluoroacetate | 98% | 79804-71-0 |
| Deslorelin Acetate | 98% | 57773-65-6 |
| Desmopressin Acetate | 98% | 16679-58-6 |
| Dynorphin A (1-13) Acetate | 98% | 72957-38-1 |
| Elcatonin Acetate | 98% | 60731-46-6 |
| Eledoisin Acetate | 98% | 69-25-0 |
| Endothelin-1 Acetate | 98% | 117399-94-7 |
| Enfuvirtide Acetate (T-20) | 95% | 159519-65-0 |
| Eptifibatide Acetate | 98% | 148031-34-9/188627-80-7 |
| Exenatide Acetate | 98% | 141732-76-5 |
| Felypressin Acetate | 98% | 56-59-7 |
| Fertirelin Acetate | 98% | 38234-21-8 |
| Ganirelix acetate | 98% | 123246-29-7 |
| GHRP-2 Acetate | 98% | 158861-67-7 |
| GHRP-6 Acetate | 98% | 87616-84-0 |
| Glatiramer Acetate | 99% | 147245-92-9 |
| GLP(7-36) | 98% | 107444-51-9 |
| GLP-1 (7-37) Acetate | 98% | 106612-94-6 |
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