Model No.: 163913-87-9
Myelin oligodendrocyte glycoprotein (MOG) is found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes and has been implicated as an important autoantigen in multiple sclerosis (MS). This peptide induces severe chronic experimental autoimmune encephalomyelitis in transgenic mice.
Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
Amino Acid Sequence
|Name||MOG 35-55 (mouse, rat)|
|3-letter-code||Met - Glu - Val - Gly - Trp - Tyr - Arg - Ser - Pro - Phe - Ser - Arg - Val - Val - His - Leu - Tyr - Arg - Asn - Gly - Lys|
|Solubilization||Soluble in pure water.|
|Description||This peptide corresponds to aa 35-55 of the Myelin Oligodendrocyte Glycoprotein (MOG) in mouse and rat.|
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