Cosmetic Peptide Ghk-Cu for Anti-Wrinkle with High Purity (GMP LAB)

Model NO.: 49557-75-7


Customized: Non-Customized


Suitable for: Adult


Purity: >98%


Color: White


Storage: Dry Cool Place


Certificate: GMP


Appearance: Blue Powder


Function: Anti-Wrinkle


Transport Package: Plastic Tube and Vial


Origin: Shanghai




Powder: Yes


Certification: GMP, HSE, ISO 9001, USP, BP


State: Solid


CAS: 49557-75-7


Type: Pharmaceutical Intermediate


Grade: Medicine Grade


MOQ: 10vial


Product Name: Ghk-Cu


Trademark: Filter


Specification: 2mg/vial


HS Code: 2801100000


Product details:

Copper peptide GHK-Cu is a naturally occurring copper complex of a glycyl-L-histidyl-L-lysine peptide. Since it has three Amino Acids it is called tripeptide. The GHK-Cu tripeptide has strong affinity for copper(II) and was first isolated from human plasma. It can be found also in saliva and urine.

Copper peptides are naturally occurring small protein fragments that have high affinity to copper ions. In human plasma, the level of GHK-Cu is about 200 µg/ml at age 20. By the age of 60, the level drops to 80 µg/ml. In humans, tripeptide GHK-Cu can promote activation of wound healing, attraction of immune cells, antioxidant and anti-inflammatory effects, stimulation of collagen andglycosaminoglycan synthesis in skin fibroblasts and promotion of blood vessels growth. Recent studies revealed its ability to modulate expression of a large number of human genes, generally reversing gene expression to a healthier state. Synthetic GHK-Cu is used in cosmetics as a reparative and anti-aging ingredient.

In the late 1980s, copper peptide GHK-Cu started attracting attention as a promising wound healing agent. Pioneers in this field were J.P Borel and F. Maquart from Université de Reims Champagne-Ardenne (France). At optimal, picomolar to nanomolar concentrations, GHK-Cu stimulated the synthesis of collagen in skin fibroblasts, increased accumulation of total proteins, glycosaminoglycans (in a biphasic curve)and DNA in the dermal wounds in rats. They also found out that the GHK sequence is present in collagen and suggested that the GHK peptide is released after tissue injury. They proposed a class of emergency response molecules which are released from theextracellular matrix at the site of an injury.[12] GHK-Cu also increased synthesis of decorin - a small proteoglycan involved in the regulation of collagen synthesis, wound healing regulation and anti-tumor defense.

The same group established that GHK-Cu stimulated both the synthesis of metalloproteinases, the enzymes which break down dermal proteins, and their inhibitors (anti-proteases). The fact that GHK-Cu not only stimulates the production of dermal components, but also regulates their breakdown suggests that it should be used with caution.



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Product Categories : Cosmetic Peptides