Adipotide Weight Loss Lyophilized Pharmaceutical Intermediate Powder Peptide Adipotide
Basic Info
Model No.: Adipotide
Product Description
Model NO.: Adipotide Customized: Customized Suitable for: Adult, Lab Research Purity: >98% Application: Pharmaceutical Appearance: Lyophilized Powder Specification: iu, mg, g, kg HS Code: 3004905910 Powder: Yes Certification: GMP State: Solid Product Name: Adipotide Color: White Trademark: Filter Origin: Shanghai Adipotide Weight Loss Lyophilized Pharmaceutical Intermediate Powder Peptide Adipotide
Production:
Aditpotide is an experimental weight loss peptidomimetic with the Amino Acid sequence CKGGRAKDC-GG-D(KLAKLAK)2, which has been developed by researchers in the United States in an effort to fight obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide. The peptide called Adipotide has been developed by U.S. researchers in the fight against the obesity . This experimental treatment has reduced by 11% the weight of the treated monkeys by reducing fatty tissue, the BMI, and waist circumference.
Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells thereby causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell death (apoptosis) of the blood vessels supplying the adipocytes. Due to the deprivation of nutrient supply, the subsequent starvation (which causes cellular atrophy or decrease in cell size) and the accumulation of waste products in the adipocytes; an irreversible injury occurs and this leads the mitochondria to release protease enzymes called caspases (specific factors that initiate the apoptotic process) which activate the transcription (a process whereby DNA is used to create mRNA) and translation (a process whereby mRNA is used to create the nascent primary peptide) of gene sequences which ultimately leads to the production of proteins that effect the apoptotic process.
Molecular studies have revealed that Adipotide possess a unique stereo-chemical (3D) conformation which enables it to bind to only two receptors in the body: ANXA-2 and prohibitin. These receptors are located on the surface of the endothelium (innermost wall lining) of the blood vessels supplying the white adipocytes, and as such, these receptors confer tissue specificity to adipotide. Formation of white adipocytes only occurs when the extent of energy consumption far exceeds energy utilization, and its (white adipocytes) formation and accumulation in the subcutaneous layer serves as a hallmark of obesity.
Applications:
Pathological studies have shown that obesity serves a risk factor for a myriad of diseases such as cancer, hypertension, endocrine disorders (such as diabetes mellitus, hyperlipidemias and metabolic syndrome), cardiovascular disease (such as stroke and myocardial infarctions) and degenerative diseases (such as osteoarthritis). Moreover, aberrant accumulation of white adipocytes predisposes the affected individual to lipoma and lipomatosis. It is well known that abdominal adiposity is mainly caused by white adipocytes, and this form of adiposity is the most lipolytically active, thus requiring a steady blood supply. Any interference with the blood supply causes it to activate the apoptotic process.
Adipotide is an experimental treatment that prevents the blood supply to fat cells. This has helped obese monkeys to lose on average 11% of their body weight in four weeks, perhaps opening the way for therapy in humans, according to a recent research study. The study, published in the journal Science Translational Medicine , shows that body mass index and waist circumference of the rhesus monkeys were reduced.
The experimental weight loss agent, "Adipotide" used by researchers at Anderson Center consists of a substance that binds to a protein on the surface of blood vessels nourishing fat cells as well as a synthetic peptide, destroying fat cells, say the authors of the study. These cells are then metabolized by the body that destroys them and excreted. An imaging test also showed a significant reduction in fatty tissue in the bodies of these animals compared to the untreated control group, the researchers suggest the Anderson Center for Research on Cancer , University of Texas (South). " The obesity as well as smoking is a major risk factor for cancer , "says Dr. Wadih Arap, professor of medicine at the Koch Center part of the University of Texas, a major sponsor of this research.
Our Services
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of producs and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Our advantages:
1. Quality:
Our company is a professional production of hormone intermediates for many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, you can trust us.
And we are the manufactory, so no problem for us to control the quality.
2.Payment method: Western Union, MoneyGram, TT, Escrow, Paypal.
3. Service: Best service with after-sales service to all clients.
4. Delivery:
Sample Order :Package will be shipped with 3days after payment. We can send it via HKems, EMS, HK Air Post, DHL or other method. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.
Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment.
After-sales service:
1.We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment...So we both can make the best of the bad bargain.
2.We will ship the goods that you order from us by EMS, DHL, UPS, or FedEx.We will decided to choose which courier depend on Different countries.To find the best way to delivery the goods for you.
3.As usual you can get the goods with in 4-7days.If the goods were lost or not received for other reasons, please contact me Immediately.
Contact us if you need more details on Pharmaceutical Intermediate. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Adipotide、Intermediate. If these products fail to match your need, please contact us and we would like to provide relevant information.
Production:
Aditpotide is an experimental weight loss peptidomimetic with the Amino Acid sequence CKGGRAKDC-GG-D(KLAKLAK)2, which has been developed by researchers in the United States in an effort to fight obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide. The peptide called Adipotide has been developed by U.S. researchers in the fight against the obesity . This experimental treatment has reduced by 11% the weight of the treated monkeys by reducing fatty tissue, the BMI, and waist circumference.
Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells thereby causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell death (apoptosis) of the blood vessels supplying the adipocytes. Due to the deprivation of nutrient supply, the subsequent starvation (which causes cellular atrophy or decrease in cell size) and the accumulation of waste products in the adipocytes; an irreversible injury occurs and this leads the mitochondria to release protease enzymes called caspases (specific factors that initiate the apoptotic process) which activate the transcription (a process whereby DNA is used to create mRNA) and translation (a process whereby mRNA is used to create the nascent primary peptide) of gene sequences which ultimately leads to the production of proteins that effect the apoptotic process.
Molecular studies have revealed that Adipotide possess a unique stereo-chemical (3D) conformation which enables it to bind to only two receptors in the body: ANXA-2 and prohibitin. These receptors are located on the surface of the endothelium (innermost wall lining) of the blood vessels supplying the white adipocytes, and as such, these receptors confer tissue specificity to adipotide. Formation of white adipocytes only occurs when the extent of energy consumption far exceeds energy utilization, and its (white adipocytes) formation and accumulation in the subcutaneous layer serves as a hallmark of obesity.
Applications:
Pathological studies have shown that obesity serves a risk factor for a myriad of diseases such as cancer, hypertension, endocrine disorders (such as diabetes mellitus, hyperlipidemias and metabolic syndrome), cardiovascular disease (such as stroke and myocardial infarctions) and degenerative diseases (such as osteoarthritis). Moreover, aberrant accumulation of white adipocytes predisposes the affected individual to lipoma and lipomatosis. It is well known that abdominal adiposity is mainly caused by white adipocytes, and this form of adiposity is the most lipolytically active, thus requiring a steady blood supply. Any interference with the blood supply causes it to activate the apoptotic process.
Adipotide is an experimental treatment that prevents the blood supply to fat cells. This has helped obese monkeys to lose on average 11% of their body weight in four weeks, perhaps opening the way for therapy in humans, according to a recent research study. The study, published in the journal Science Translational Medicine , shows that body mass index and waist circumference of the rhesus monkeys were reduced.
The experimental weight loss agent, "Adipotide" used by researchers at Anderson Center consists of a substance that binds to a protein on the surface of blood vessels nourishing fat cells as well as a synthetic peptide, destroying fat cells, say the authors of the study. These cells are then metabolized by the body that destroys them and excreted. An imaging test also showed a significant reduction in fatty tissue in the bodies of these animals compared to the untreated control group, the researchers suggest the Anderson Center for Research on Cancer , University of Texas (South). " The obesity as well as smoking is a major risk factor for cancer , "says Dr. Wadih Arap, professor of medicine at the Koch Center part of the University of Texas, a major sponsor of this research.
Our Services
The quality control process
1)Purchasing
Thorough market research, understand the price of raw materials and performance.To the procurement source to understand fully, and fully guarantee the quality of the procurement of raw materials.
2) Inspection
Four steps: sampling, sample pretreatment, measuring and data processing.
3) Producing
a)Each operator must do self-inspection of producs and make the corresponding inspection records.
b)Full-time inspectors through check the operator self-inspection, and review and sign in the corresponding record. Full-time inspection is responsible for inspection of finished product, and make the finished product incoming inspection records.
4) Before selling
Test result can be provided before selling.
Third-party detection institution is allowed if you are not satisfied with test results.
Our advantages:
1. Quality:
Our company is a professional production of hormone intermediates for many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, you can trust us.
And we are the manufactory, so no problem for us to control the quality.
2.Payment method: Western Union, MoneyGram, TT, Escrow, Paypal.
3. Service: Best service with after-sales service to all clients.
4. Delivery:
Sample Order :Package will be shipped with 3days after payment. We can send it via HKems, EMS, HK Air Post, DHL or other method. We have a professional and stable logistics, and we can deliver the package smoothly around 3 to 5 days.
Bulk Order: Shipped via sea or air, it's according to your requirement, delivery time is 7-15days after payment.
After-sales service:
1.We will ship the goods within 5days after get your payments.If you want to cancel or change order, please tell me within 24hours after you finish the payment...So we both can make the best of the bad bargain.
2.We will ship the goods that you order from us by EMS, DHL, UPS, or FedEx.We will decided to choose which courier depend on Different countries.To find the best way to delivery the goods for you.
3.As usual you can get the goods with in 4-7days.If the goods were lost or not received for other reasons, please contact me Immediately.
Contact us if you need more details on Pharmaceutical Intermediate. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Adipotide、Intermediate. If these products fail to match your need, please contact us and we would like to provide relevant information.
Product Categories : Pharmaceutical Intermediate
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