High Quality Myostatin Gdf-8 for Adult with GMP (ODM)

Model NO.: API Customized: Customized Suitable for: Adult Purity: 85% Certificate: GMP Storage: Dry Cool Place Packing: 10vials Per Kits Specification: 1mg/vial HS Code: 3003901000 Powder: Yes Certification: GMP State: Solid Name: Myostatin Gdf-8 Supply Ability: 1000 Kits Per Month Appearance: White Powder Trademark: FILTER Origin: Shanghai Product name: Myostatin GDF-8
Purity:85%
Specification:1mg/vial
Appearance:White powder
Storage:Dry Cool Place
Grade:Medicine Grad
Packing:10vials per kits
Type:API

Product Description
Pharmaceutical Intermediate Myostatin pure powder

Product Description
Myostatin
Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation. In humans it is encoded by the MSTN gene. Myostatin is a secreted growth differentiation factor that is a member of the TGF beta protein family.
Animals either lacking myostatin or treated with substances that block the activity of myostatin have significantly more muscle mass. Furthermore, individuals who have mutations in both copies of the myostatin gene have significantly more muscle mass and are stronger than normal. Blocking the activity of myostatin may have therapeutic application in treating muscle wasting diseases such as muscular dystrophy.
 
Discovery and sequencing
The gene encoding myostatin was discovered in 1997 by geneticists Se-Jin Lee and Alexandra McPherron who produced a strain of mutant mice that lack the gene. These myostatin "knockout" mice have approximately twice as much muscle as normal mice. These mice were subsequently named "mighty mice".
Naturally occurring deficiencies of myostatin have been identified in cattle by Ravi Kambadur, whippets, and humans; in each case the result is a dramatic increase in muscle mass. A mutation in the 3' UTR of the myostatin gene in Texel sheep creates target sites for the microRNAs miR-1 and miR-206. This is likely to cause the muscular phenotype of this breed of sheep.
 
Structure and mechanism of action
Human myostatin consists of two identical subunits, each consisting of 109 (NCBI database claims human myostatin is 375 residues long) Amino Acid residues. Its total molecular weight is 25.0 kDa. The protein is inactive until a protease cleaves the NH2-terminal, or "pro-domain" portion of the molecule, resulting in the active COOH-terminal dimer. Myostatin binds to the activin type II receptor, resulting in a recruitment of either coreceptor Alk-3 or Alk-4. This coreceptor then initiates a cell signaling cascade in the muscle, which includes the activation of transcription factors in the SMAD family - SMAD2 and SMAD3. {{|}}These factors then induce myostatin-specific gene regulation. When applied to myoblasts, myostatin inhibits their differentiation into mature muscle fibers.
Myostatin also inhibits Akt, a kinase that is sufficient to cause muscle hypertrophy, in part through the activation of protein synthesis. However, Akt is not responsible for all of the observed muscle hyperthrophic effects which are mediated by myostatin inhibition[8] Thus myostatin acts in two ways: by inhibiting muscle differentiation, and by inhibiting Akt-induced protein synthesis.
 
Clinical significance
Mutations
A technique for detecting mutations in myostatin variants has been developed. Mutations that reduce the production of functional myostatin lead to an overgrowth of muscle tissue. Myostatin-related muscle hypertrophy has an incomplete autosomal dominance pattern of inheritance. People with a mutation in both copies of the MSTN gene in each cell (homozygotes) have significantly increased muscle mass and strength. People with a mutation in one copy of the MSTN gene in each cell (heterozygotes) have increased muscle bulk, but to a lesser degree.
In 2004, a German boy was diagnosed with a mutation in both copies of the myostatin-producing gene, making him considerably stronger than his peers. His mother has a mutation in one copy of the gene. An American boy born in 2005 was diagnosed with a clinically similar condition but with a somewhat different cause: his body produces a normal level of functional myostatin; but, because he is stronger and more muscular than most others his age, it is believed that a defect in his myostatin receptors prevents his muscle cells from responding normally to myostatin. He appeared on the television show, World's Strongest Toddler.
 
Therapeutic potential[edit]
Further research into myostatin and the myostatin gene may lead to therapies for muscular dystrophy. The idea is to introduce substances that block myostatin. A monoclonal antibody specific to myostatin increases muscle mass in mice and monkeys.
 
A two-week treatment of normal mice with soluble activin type IIB receptor, a molecule that is normally attached to cells and binds to myostatin, leads to a significantly increased muscle mass (up to 60%).[33] It is thought that binding of myostatin to the soluble activin receptor prevents it from interacting with the cell-bound receptors.
 
It remains unclear as to whether long-term treatment of muscular dystrophy with myostatin inhibitors is beneficial, as the depletion of muscle stem cells could worsen the disease later on. As of 2012, no myostatin-inhibiting drugs for humans are on the market. An antibody genetically engineered to neutralize myostatin, stamulumab, which was under development by pharmaceutical company Wyeth., is no longer under development. Some athletes, eager to get their hands on such drugs, turn to the internet where fake "myostatin blockers" are being sold.
 
Myostatin levels are effectively decreased by creatine supplementation.


----------Additional Information  ------------
Brand: Filter
Package:Plastic Tube
Place of origin:China
Certificate: GMP

-----------Delivery Information  -------------
Packing : Plastic Tube/vials or as your request
Payment : T/T, Western Union
Port : Shanghai, Shenzhen,Gunagzhou Hongkong
Shipment method : EMS,TNT, DHL, FeDex, UPS, etc
Leading  time : Within 24 hours after payment
Delivery time : safe & timely, around 3 days after payment.

----------Our Competitive Advantages  -----------
1.Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years
2.Superior quality, purity and favourable.
Our company is a professional leading manufacturer in China in pharmaceutical area.Good quality is one of our secret success.
3.Safe and fast delivery.
We have GOLDEN FORWARDER and UK Warehouse  so we can delivery quickly and safely.
4.Package: Professional packing with professional materials.
5.Competitive Prices : Low price with high qulity.


                                       Peptide  List

Product Name	Purity	Specification
Dynorphin A (1-13) Acetate	95%min	10mg/vial,  10vial/kit
GHRP-2	98%min	5mg/vial,  10vial/kit
GHRP-6	98%min	5mg/vial,  10vial/kit
CJC-1295without DAC(CJC-1293)	98%min	2mg/vial,  10vial/kit
CJC-1295 (DAC)	98%min	2mg/vial,  10vial/kit
Sermorelin Acetate	98%min	2mg/vial,  10vial/kit
	98%min	0.1mg/vial,1mg/vial,  10vial/kit
Enfuvirtide Acetate (T-20)	98%min	10mg/vial,  10vial/kit
PT-141	98%min	10mg/vial,  10vial/kit
Hexarelin	98%min	2mg/vial,  10vial/kit
MT-II (Melanotan II )	98%min	10mg/vial,  10vial/kit
Sermorelin Aceta	98%min	5mg/vial,  10vial/kit
Ipamorealin	98%min	2mg/vial,  10vial/kit
TB-500(Thymosin β4 Acetate)	98%min	2mg/vial,5mg/vial,10mg/vial, 10vial/kit

Should any interest on any of the above peptides, welcome to contact us.
 

Contact us if you need more details on Antibody. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Pharmaceutical Intermediate、Steroids Powder. If these products fail to match your need, please contact us and we would like to provide relevant information.

Product Categories : Pharmaceutical Peptides